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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
30
Human Site:
S1375
Identified Species:
47.14
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S1375
P
K
Y
T
F
D
F
S
E
E
E
D
D
D
A
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1383
P
K
Y
T
F
D
F
S
E
E
E
D
D
D
A
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1369
P
K
Y
T
F
D
F
S
E
E
E
D
D
D
A
Dog
Lupus familis
XP_534241
2041
231068
S1793
P
K
Y
T
F
D
F
S
E
E
E
D
D
D
A
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S1363
P
K
Y
T
F
D
F
S
E
E
E
D
D
D
A
Rat
Rattus norvegicus
P41516
1526
173202
S1295
N
P
W
S
D
S
E
S
D
M
S
S
N
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S1678
P
K
Y
T
F
D
F
S
E
E
E
D
D
A
D
Chicken
Gallus gallus
O42131
1627
183228
S1380
A
K
Y
T
F
D
F
S
K
E
E
D
D
A
H
Frog
Xenopus laevis
NP_001082502
1579
178601
E1345
S
D
E
E
S
A
K
E
E
S
S
L
K
K
S
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
T1377
S
A
V
K
A
K
Y
T
F
D
F
S
E
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
G1216
R
K
V
K
S
M
G
G
G
A
G
A
G
D
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1289
A
T
K
A
K
Y
E
K
M
S
Q
P
K
K
E
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
T1217
E
D
E
S
S
G
L
T
G
V
S
S
K
M
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
K1242
N
N
V
A
E
V
V
K
P
K
A
R
Q
G
A
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
V1197
G
K
G
K
R
K
L
V
D
D
E
D
Y
D
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
86.6
73.3
6.6
0
N.A.
13.3
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
46.6
N.A.
86.6
80
13.3
33.3
N.A.
13.3
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
0
14
7
7
0
0
0
7
7
7
0
14
40
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
0
0
7
47
0
0
14
14
0
54
47
47
7
% D
% Glu:
7
0
14
7
7
0
14
7
47
47
54
0
7
14
14
% E
% Phe:
0
0
0
0
47
0
47
0
7
0
7
0
0
0
0
% F
% Gly:
7
0
7
0
0
7
7
7
14
0
7
0
7
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
60
7
20
7
14
7
14
7
7
0
0
20
14
0
% K
% Leu:
0
0
0
0
0
0
14
0
0
0
0
7
0
0
0
% L
% Met:
0
0
0
0
0
7
0
0
7
7
0
0
0
7
0
% M
% Asn:
14
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% N
% Pro:
40
7
0
0
0
0
0
0
7
0
0
7
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% Q
% Arg:
7
0
0
0
7
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
14
0
0
14
20
7
0
54
0
14
20
20
0
0
14
% S
% Thr:
0
7
0
47
0
0
0
14
0
0
0
0
0
0
7
% T
% Val:
0
0
20
0
0
7
7
7
0
7
0
0
0
0
7
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
47
0
0
7
7
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _